Acquired immunedeficiency syndrome AIDS

Humphreys MH, Schoenfeld PY. Renal complications in patients with the acquired immunedeficiency syndrome (AIDS). American journal of nephrology. 1987 7(l) l-7. 

Once an individual has become immune through previous infection, vaccination, or by passive transmission of maternal antibody, these specific defenses effectively control most viral and bacterial pathogens. Depletion of the CD4+ T-lymphocyte population, as occurs in acquired immunedeficiency syndrome (AIDS) leads to a general reduction in immune competence and an increased susceptibility to infectious and neoplastic disease (22). Similarly, IgA deficiency can result in increased risk of respiratory tract infection (23). 

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