Acid phenylphosphatase

Tartrate is a most widely used inhibitor of prostatic acid phenylphosphatase activity. With this inhibitor Bonner and associates detected five cases of unsuspected carcinoma of the prostate in 221 hospital patients and clarified the diagnoses in another four patients (98). Nonetheless, the diagnostic specificity of an elevated 1-tartrate inhibited activity is not absolute, as Fishman et. al found it elevated in 48 of 1,190 males without cancer. Whitmore and associates also observed this activity to be elevated in 3 of 20 patients with uncomplicated nodular hyperplasia (102). Hill compared the total versus the "prostatic" serum activities in 20 patients with localized untreated carcinoma of the prostate and observed... 

As the preceding considerations illustrate and as was noted at the beginning of this section (2.1), comparison of acid phosphatase activities obtained in different studies must take into account the method employed. Some workers have attempted to do this by using the terms 8-glycerophosphatase, phenylphosphatase, etc. to designate the substrate employed (B6, T6). However, such usage may imply that different acid phosphatases are responsible for these actions, and we shall therefore attempt to avoid this usage in the present review. 

V2. Vaes, G., and Jacques, P., Studies on bone enzymes. Distribution of acid hydrolases, alkaline phenylphosphatases, cytochrome oxidase and catalase in subcellular fraction of bone tissue homogenate. Biochem. J. 97, 389-392 (1965). 

Lin and Fishman (1972) prepared subcellular fractions of homogenates of mouse kidney and assayed them for the activities of acid phosphatase (phenylphosphatase, )3-glycerophosphatase), )3-glucuronidase, glu-cose-6-phosphatase, and succinic dehydrogenase. As shown in Fig. 10,... 

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