Acid chlorides, preparation from

From the acid chloride. By the interaction of the acid chloride (prepared from the acid and thionyl chloride) and the calculated quantity of the alcohol at 0°, for example ... 

To 1 gramm-equivalent (g-eq) of dimethylaminoethanethiol in 150 ml of ether, a suspension of g-eq of 50% sodium hydride in 50-ml of anhydrous ether was added. After boiling for 1 hour, the reaction mixture was cooled to 0°C, whereupon g-eq of 9,9-dimethylacridan-10-carboxylic acid chloride (prepared from 9,9-dimethylacridan and phosghene - cf. Swiss Specification No. 

A list of ketones which have been prepared by the Friedel-Crafts stannic chloride method may be found in Table VI. Yields marked by an asterisk were obtained from acid chlorides prepared by the phosphorus pentachloride procedure all others were obtained from acid chlorides prepared from thionyl chloride. 

From the acid chloride (prepared from the acid and thionyl chloride) and aniline in benzene or in ether For directions and examples see Cheronis, p 445, Linstead, p 14, Shrmer, pp 98, 200-1, Vogel, pp 361, 369, 458, Wild, p 182, P W Robertson, y Chem Soc, 115, 1210 (1919)... 

A soln. of vitamin A acid chloride (prepared from the acid and PC/g) in dioxane added dropwise during 10 min. at 10° to a vigorously stirred soln. of Na-retinoyl-hydroxamate prepared by addition of aq. NaOH to the hydroxamic acid in dioxane, and stirred 3 hrs. at 20° in a closed flask in the dark N,0-diretinoyl-hydroxylamine. Overall Y 73.4%. R. Miller, Chim. Therap. 9, 298 (1974). 

Acid Chlorides. TBDMS esters, when treated with DMF and oxalyl chloride in methylene chloride at 0 °C, give the corresponding acid chlorides in excellent yields under neutral conditions (eq 14). Similarly, W-carboxyamino acid anhydrides were prepared via the intermediacy of an acid chloride prepared from a TBDMS ester (eq 15). ... 

J13,17a-l7.Keto-D-homosteroids. Anhydrous Cd-chloride added portion wise to methylmagnesium bromide from methyl bromide and Mg-turnings in ether, refluxed 2 hrs., filtered under Ng, the efficiently stirred filtrate treated drop-wise with Jf>13(18)-3-keto-13,17-seco-androstadien-17-ic acid chloride (prepared from 550 mg. acid and oxalyl chloride), and refluxed 2 hrs. 250mg. J4,l3(l7a). 3,17-diketo-18-nor-D-homoandrostadiene. F. e. s. H. Heusser et al., Helv. 42, 2140 (1959). 

Startg. acid chloride (prepared from the acid with oxalyl chloride) allowed to react at -15° with SnGl4 in GSg product. Y 84%. R. R. Sobti and S. Dev, Tetrah. Let. 1967, 2893. 

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