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Acid chlorides lithium dialkylcuprates

To stop at the ketone stage, a weaker organometallic reagent is needed one that reacts faster with acid chlorides than with ketones. Lithium dialkylcuprates and other organocuprates (Section 17-13a) react with acid chlorides to give good yields of a wide variety of ketones. [Pg.836]

Grignard and organolithium reagents add twice to acid chlorides to give 3° alcohols (after hydrolysis). Lithium dialkylcuprates add just once to give ketones. Sodium boro-hydride or lithium aluminum hydride adds hydride twice to acid chlorides, reducing... [Pg.1019]

However, good yields of ketones can be obtained for an equivalent quantity of acid halide per group attached to copper. Suitable conditions exist for the coupling of dialkylcuprates with acid chlorides which contain other functional groups (233), such as carbonyl, carboxy, and cyano. The order of reactivity of these groups towards organocopper compounds is CHO > CO > COgR > CN. Benzoyl fluoride reacts very slowly with lithium dimethylcuprate. [Pg.279]

Acylation of Lithium Dialkylcuprates with Acid Chlorides or Thiol Esters... [Pg.397]

Reaction of lithium dialkylcuprates with acid chlorides (17.2, 18.6, 22.10)... [Pg.1086]

See other pages where Acid chlorides lithium dialkylcuprates is mentioned: [Pg.124]    [Pg.124]    [Pg.836]    [Pg.265]    [Pg.124]    [Pg.426]    [Pg.426]    [Pg.859]    [Pg.1015]    [Pg.426]    [Pg.724]    [Pg.76]   
See also in sourсe #XX -- [ Pg.428 ]

See also in sourсe #XX -- [ Pg.428 ]



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