ACID Basics Getting Around

Fortunately, learning the workspace is a simple process. This chapter starts by noting some of the different ways you can use ACID. The remainder serves as a full introduction and reference to all of the various parts of ACID. Individual controls and windows are explained more fully in later chapters as they become relevant. Although the focus of this book is on more advanced topics, musical composition, and taking ACID to the next level, a solid gronnding in the fundamentals is the necessary first step. 

---

Chapter 1, ACID Basics Getting Around — A short but comprehensive tour of the workspace. This chapter is a one-stop reference to all of the pieces and parts that make up ACID. 

Table 1.1 Top-ten ACID shortcuts. ACID Basics Getting Around - Chapter 1 21... 

The silica on tic plates is acidic in nature, and so compounds that are sensitive to acid may well decompose on tic. There are several ways of getting around this problem, you can use alumina tic plates (these suffer from the disadvantage that resolution is generally not as good, and the plates are basic in nature), or alternatively you can add a small amount of an amine (usually ammonia or triethylamine) to the solvent mixture to neutralize the acidic sites on the silica. 

To get around this, a variety of coupling reagents have been developed that first react with the acid or carboxylate to form an active acyl compound, which is basic enough to deprotonate an ammonium and electrophilic enough to react with the free base of the amine. A common coupling agent is dicyclohexylcarbodiimide, or DCC, which is very toxic. 

To get around this problem using a basic quadru-pole system, either another isotope of the element of interest has to be monitored or an elemental correction equation needs to be applied. This is common methodology used to analyze clinical samples. However, if the trace metal levels in the sample are extremely low or sample preparation necessitates the use of an acid/sol-vent that contains one of the interfering ions (e.g., CF or N+), this approach struggles. For that reason, ultratrace levels in some clinical samples require the use of ... 

Ion-exchange resins have also served as catalysts [32-35]. However, the resin gets completely deactivated at around 200°C, and the safe working temperature is around 125°C. Strongly acidic resins are prepared by sulfonation of polystyrene gels. Strongly basic resins are obtained by the amination of chloromethylated resins by tertiary amines such as trimethyl amine ... 

---