Acetylcholinesterase isoenzymes

Eldefrawi, M. E., Tripathi, R. K. and O Brien, R. D. (1970) Acetylcholinesterase isoenzymes from the housefly brain. Biochim. biophys. Acta (Artist.), 212, 308-314. 

Cambon, C,. Deelume, C.. and Deraehe, R. (1980). Fetal and maternal rat brain acetylcholinesterase isoenzymes changes following insecticidal carbamate derivatives poisoning. Arch. 7anccj/. 45, 257-262. 

L6. Lenz, D. E., and Maxwell, D. M., Inhibition of rat cerebrum acetylcholinesterase isoenzymes after acute administration of soman. Biochem. Pharmacol. 30, 1369-1371 (1981). 

Baldwin, J., and P.W. Hochachka (1970). Functional significance of isoenzymes in thermal acclimatization acetylcholinesterases from trout brain. Biochem. J. 116 883-887. 

Srinlvasan, R., Karezmar, A.G., and Bershon, J., 1976 Rat brain acetylcholinesterase and Its Isoenzymes after Intracerebral administration of DFP. Biochem. Pharmacol. 25 2739-2745. 

Acetylcholinesterase bimolecular rate constants for inhibition by organophosphates and carbamate, 53r consequences of existence of isoenzymes in insects, 54... 

Cholinesterase levels vary from species to species and from strain to strain within a species, and also with the age of the animal (Augustinsson, 1963 Usdin, 1970). Isoenzymes have been demonstrated for pseudocholinesterase on numerous occasions (Webb, 1964). The reports of isoenzymes among acetylcholinesterases are fewer. Ecobichon and Israel (1967) found 4. Isoenzymes of acetylcholinesterase in the electric eel. Isoenzymes of acetylcholinesterase seem common in insects. They have been demonstrated in the cricket (Edwards and Gomez, 1966), housefly and cockroach (Eldefrawi et al., 1970) and the mayfly (Krysan and Kruckeberg, 1970). 

B9. Bajgar, J., and Parizek, J., Changes of acetylcholinesterase and esterase isoenzymes in isolated cerebellar cortex of the rabbit. Brain. Res. 57, 299-305 (1973). 

The substances discussed in this section have become important because of their property of acylating esterases, particularly acetylcholinesterase (AChase). The death of insects correlates well with the inhibition of their AChase, provided that thoracic (but not brain) isoenzyme is tested (Bigley, 1966 Farnham, Gregory and Sawicki, 1966). Similarly the toxicity oforgano-phosphates to mammals is directly proportional to the inhibition of their AChase (Aldridge and Barnes, 1952). 

---