Acetylcholinesterase inhibitors prevention/treatment

Scopolamine causes spatial learning and memory deficits that involved activation of glycogen synthase kinase-3 3 (GSK-3P) and impairments of dendrite arborization and spine formation/ maturation associated with alterations of AMPAR, Homerl, and CREB. Pretreatment by intraperitoneal injection of lithium, an inhibitor of GSK-3, for 1 week prevented the synaptic changes and the learning and memory deficits induced by scopolamine. Lithium treatment also activated cholineacetyltransferase and inhibited acetylcholinesterase, which might have also contributed to the improved memory [531],... 

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