Acetylcholinesterase induction

Casaco A, Garcia M, Gonzalez R, et al. 1985b. Induction of acetylcholinesterase inhibition in the guinea pig trachea by kerosene. Respiration 48(l) 46-49. 

Even more reactive towards acetylcholinesterase are the organophosphorus derivatives developed as chemical warfare nerve agents, e.g. sarin. Such compounds react readily with the enzyme and form very stable addition intermediates. It is unusual to see fluoride as a leaving group, as in sarin, but its presence provides a huge inductive effect, thus accelerating the initial nucleophilic addition step (see also Section 13.7). 

Prager, KM., Aroniadou-Anderjaska, V., Almeida-Suhetb CP, et al., 2013. Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure. Neurotoxicology 38,84-90. 

Zhang, XJ., Yang, L., Zhao, Q., et al., 2002. Induction of acetylcholinesterase e)q>ression during apoptosis in various cell types. Cell Death Differ. 9,790-800. 

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