Acetylcholine receptor, function

Nicotinic Acetylcholine Receptor Function Studied with Synthetic (+)-Anatoxin-a and Derivatives... 

Buisson, B., Bertrand, D. Chronic exposure to nicotine upregulates the human a4(32 nicotinic acetylcholine receptor function. J. Neurosci. 21 1819, 2001. 

Buisson B, Bertrand D (2001) Chronic exposure to nicotine upregulates the human alpha4beta2 nicotinic acetylcholine receptor function. J Neurosci 21 1819-1829 CeUe PH, van Rossum-Fikkert SE, van Dijk WJ, Brejc K, Smit AB, Sixma TK (2004) Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron 41 907-914... 

Hann, et al. Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function. J Neurosci Res... 

Yamada M, Basile AS, Fedorova I, et al. Novel insights into M5 muscarinic acetylcholine receptor function by the use of gene targeting technology. Life Sci. 2003 74 345-353. 

Brown DA, Buckley NJ, Caulfield MP et al (1995) Coupling of muscarinic acetylcholine receptors to neural ion channels closure of K+ channels in Molecular Mechanisms of Muscarinic Acetylcholine Receptor Function, ed. J. Wess (Austin, Tx R.G. Landes Co.)... 

Anholt, R Fredkin, D.R., Deerinck, T., Ellisman, M., Montal, M Lindstrom, J. (1982). Incorporation of acetylcholine receptors into liposomes. Vesicle structure and acetylcholine receptor function. J. Biol. Chem. 257, 7122-7134. 

Wess J. 1993. Molecular basis of muscarinic acetylcholine receptor function. Trends Pharmacol Sci 14 308-313. 

Swanson, K.L., Rapoport, H., Aronstam, R.S., and Albuquerque, E.X. 1990. Nicotinic acetylcholine receptor function studied with synthetic (+)-anatoxin-a and derivatives. In ACS Symposium Series Marine Toxins, vol. 418, ed. Hall, S., and Strichartz, G. Washington, DC American Chemical Society, 107-118. 

The biogenesis of both acetylcholine receptor and chromaffin granules share several common properties. The specific polypeptides are synthesized and transported into the membrane by a vectorial translation process. The specific proteins are sorted out by the Golgi apparatus and eventually fuse with the plasma membrane via the secretory pathway. Yet the acetylcholine receptor functions on the plasma membrane, and therefore it should stay on this membrane for a long time (2-7 days). On the other hand, the function of chromaffin granules is to store neurotransmitters. Therefore they stay most of their lifetime inside the cell and their fusion with the plasma membrane is temporary. Soon after the secretion process, the constituents of the chromaffin granule membrane must be removed from the plasma membrane by endocytosis. 

Hunter, D., and Nathanson, N. (1985). Assay of Muscarinic Acetylcholine Receptor Function in Cultured Cardiac Cells by Stimulation of Rb Efflux, Anal. Biochem. 149 392-398. 

Barrantes FJ. Structural basis for Hpid modulation of nicotinic acetylcholine receptor function. Brain Res Brain Res Rev. 2004 47(l-3) 71-95. 

Narayanaswami, V. Kim, J. McNamee, M. G. Protein-lipid interactions and Torpedo californica nicotinic acetylcholine receptor function. 1. Spatial disposition of cysteine residues in the y subunit analyzed by fluorescence-quenching and... 

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