Acetogenins antitumor activity

The synthesis of unsynunetrical nonadjacently linked tetrahydrofurans was accomplished by Mootoo through (4a) catalyzed cross metathesis of the protected substituted-tetrahydrofuran components. These compounds are potential intermediates for acetogenins having potent antitumor activity... 

In addition to their potential as antitumor agents, acetogenins have great potential as natural "organic" pesticides (Mikolajczak et al., 1988,1989 McLaughlin et al., 1997). Bullata-cin (1) and trilobacin (3) (see Figure 13.1) were more potent than rotenone, a classic complex I mitochondrial inhibitor, in a structure-activity relationship (SAR) study using yellow fever mosquito (YFM) larvae (He et al., 1997). 

Morre, D.J., Cabo, R.D., Farley, C., Oberlies, N.H., and McLaughlin, J.L. Mode of action of bullatacin, a potent new antitumor acetogenin inhibition of NADH oxidase activity of HELA and HL-60, but not liver plasma membranes. Life Sci.., 56, 343, 1995. 

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