Acetogenin mimics cytotoxicity

The cytotoxic results of mimics 232a-d toward some caner cells are shown in Table 10-4. As can be seen, maintenance of the two free hydroxy groups originally flanking Z w-THF rings of acetogenin proved to be rewarding, and these mimics... 

To get more information about the SAR of acetogenin or its mimics, we synthesized 238a-d, which have no butenolide unit, and butenolides 239, which lack the THF ring or glycol ether unit. These compounds showed no or weak cytotoxicity, which indicated that both the butenolide segment and the glycol ether unit were indispensable. The stereochemistry of the chiral center in the butenolide... 

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