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Acetogenin mimics

Scheme 10-43. Parallel fragment assembly strategy for a small library of acetogenin mimics... Scheme 10-43. Parallel fragment assembly strategy for a small library of acetogenin mimics...
Synthesis and Inhibitory Action of Novel Acetogenin Mimics Alac-Acetogenins A New Class of Inhibitors of Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex-I)... [Pg.171]

I 18 Synthesis and Inhibitory Action of Novel Acetogenin Mimics Alac-Acetogenins... [Pg.172]

RECENT PROGRESS ON THE CHEMICAL SYNTHESIS OF ANNONACEOUS ACETOGENINS AND THEIR STRUCTURALLY MODIFIED MIMICS... [Pg.399]

Scheme 10-38. Yao et al. s first generation of mimics for mono- and fcw-THF acetogenins. Scheme 10-38. Yao et al. s first generation of mimics for mono- and fcw-THF acetogenins.
The cytotoxic results of mimics 232a-d toward some caner cells are shown in Table 10-4. As can be seen, maintenance of the two free hydroxy groups originally flanking Z w-THF rings of acetogenin proved to be rewarding, and these mimics... [Pg.430]

To get more information about the SAR of acetogenin or its mimics, we synthesized 238a-d, which have no butenolide unit, and butenolides 239, which lack the THF ring or glycol ether unit. These compounds showed no or weak cytotoxicity, which indicated that both the butenolide segment and the glycol ether unit were indispensable. The stereochemistry of the chiral center in the butenolide... [Pg.431]

Chemical synthesis of annonaceous acetogenins and their structurally modified mimics... [Pg.461]

See other pages where Acetogenin mimics is mentioned: [Pg.428]    [Pg.429]    [Pg.432]    [Pg.437]    [Pg.172]    [Pg.428]    [Pg.429]    [Pg.432]    [Pg.437]    [Pg.172]    [Pg.241]    [Pg.428]    [Pg.429]    [Pg.429]    [Pg.431]    [Pg.432]    [Pg.433]    [Pg.433]    [Pg.435]   


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Acetogenin mimics cytotoxicity

Mimicing

Mimics

Recent Progress on the Chemical Synthesis of Annonaceous Acetogenins and Their Structurally Modified Mimics

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