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Acetic acid incorporation into plant alkaloids

It is difficult to reconcile the unique chemical structure of tetrodotoxin with that of an animal product. Its structure is not related to that of other animal products by any readily recognized biosynthetic scheme. It is not a terpenoid, not obviously formed from amino acid or carbohydrate units, and apparently not constructed from acetate or propionate units. Nor does it resemble any of the various plant alkaloid patterns. It thus appears to be a very unlikely animal product to result from known biogenetic pathways. In this connection the metabolic incorporation of radioactive precursors using torosa and ]C. granulosa salamanders was studied by Shimizu et al. (47). They observed significant isotopic incorporation into amino acids and steroid metabolites, but they found no such incorporation associated with tetrodotoxin. [Pg.339]

Acetate has been reported to be a precursor for the necic acid component, monocrotalic acid [as (48)], of monocrotaline (49). Rigorous attempts to confirm this finding have met only with failure. Although acetate was rapidly taken up into the plant it was not incorporated into (49). The earlier conclusion, it was suggested, may have been occasioned by working with impure alkaloid. [Pg.12]

Polyketides occuring in plants are not always exclusively synthesized from acetate units, but often are of mixed biosynthetic origin. Phenylpropanoid or terpenoid building blocks or sometimes both can be connected with the acetate-derived backbone. In addition, parts of the carbon skeleton can be derived from fatty acids or amino acids. This mixed assembly principle results in a plethora of structurally diverse compounds. Polyketide alkaloids obtained when nitrogen or nitrogen-containing precursors are incorporated into the polyketide backbone will also be discussed. [Pg.27]


See other pages where Acetic acid incorporation into plant alkaloids is mentioned: [Pg.552]    [Pg.552]    [Pg.552]    [Pg.211]    [Pg.5]    [Pg.532]    [Pg.202]    [Pg.116]   
See also in sourсe #XX -- [ Pg.96 , Pg.98 , Pg.99 , Pg.103 , Pg.105 , Pg.110 , Pg.132 , Pg.137 ]




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