Acetamido-2-deoxy-D-galactose 6-sulphate Sulphatases

2-Acetamido-2-deoxy-i -galactose 4-Sulphate Sulphatases.—Extracts of skin fibroblasts obtained from patients with Maroteaux-Lamy syndrome exhibited a marked reduction in 2-acetamido-2-deoxy-D-galactose 4-sulphate sulphatase activity towards chondroitin 4-[ S]sulphate and a heptasaccharide derived therefrom.  

A purified 2-acetamido-2-deoxy-D-galactose 4-sulphate sulphatase from human placenta has been shown to be identical with an arylsulphatase B from the same source. The levels of the two enzymes were compared in cases of Maroteaux-Lamy syndrome. UDP-2-Acetamido-2-deoxy-D-galactose 4-sulphate is the natural substrate for the former sulphatase. 

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A sulphatase, which liberates sulphate from UDP-2-acetamido-2-deoxy-D-galactose 6-sulphate (the nucleotide occurring in quail egg white at high concentration), has been isolated from quail oviduct.The tissue also contained sulphatase activities for UDP-2-acetamido-2-deoxy-D-galactose 4-sulphate and nitrocatechol sulphate but these activities were removed from the 6-sulphatase fraction during purification. The UDP-2-acetamido-2-deoxy-D-galactose 6-... 

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