Acetals reaction with bases

Bu4N F , THF, 25°, I h, >90% yield. Fluoride ion is very basic, especially under anhydrous conditions, and thus may cause side reactions with base-sensitive substrates. The strong basicity can be moderated by the addition of acetic acid to the reaction, as was the case in the following reaction, after all others methods failed to remove the TBDMS group. ... 

An analogous scheme is used for the synthesis of the cardiotonic agent milrinone [28]. The key aminoformyl derivative (26-2) is obtained in this case by condensation of 4-pyridylacetone (26-1) with DMF acetal. Reaction with cyanoacetamide in the presence of a strong base proceeds exactly as above to give the pyridone (26-3) by a parallel set of transformations. Note that the nitrile is left as such in this drug. 

Acetic acid shows all the characteristic properties of carboxylic acids. Hydrogen gas and acetate salts are formed upon reaction with metals and it undergoes neutralization reactions with bases and basic salts. 

MURIATIC ACID (7647-01-0) HCl For anhydrous form see hydrogen chloride. Hydrogen chloride gas is quickly absorbed in water, forming hydrochloric acid, a strong acid. Violent reaction with bases, amines, amides, inorganic hydroxides strong oxidizers (with release of chlorine gas), acetic anhydride, borides, calcium carbide carbonates, cesium acetylide cesium cyanotridecahydrodecaborate (2-) 1,1-... 

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