Acetal lactone

Open-chain carbon skeletons (including cyclic acetals, lactones, lactams, cyclic anhydrides, etc.)... 

Dioxanone derivatives.1 The optically active 1,3-dioxanone (acetal lactone) 1 is obtained by reaction of (R)-3-hydroxybutyric acid with pivalaldehyde in the presence of an add catalyst. These derivatives can be used to effect enantio-selective reactions at the 2-, 3-, and 4-positions of (R)-3-hydroxybutyric acid. Thus,... 

Two thioacetates, thiofurodysin acetate (320) and thiofurodysinin acetate (209) were isolated from a Dysidea species from Sydney, Australia. They were converted by treatment with Raney nickel to a mixture containing furodysin and furodysinin respectively [214], These were the first thiol acetates isolated from natural sources. The absolute configurations of (-)-(6/ ,ll/ )-thiofurodysinin acetate (209), (-)-(6/ ,ll/ )-furodysinin disulfide (208) and (+)-(6/ ,ll/ )-methoxythiofurodysinin acetate lactone (321), isolated from a Fijian specimen of D. herbacea were determined by chemical interconversion [292]. 

Polyhydroxy- phenols. amino acids, di- and polyamino compounds, amino alcohols. Sulphonic acids. Sulphinic acids. Salts. sulphinic acids, aminosulphonic acids and sulphonamides. Some diketones and /3-keto esters. Ethers and acetals. Lactones. Acyl halides. Diaryl ethers. intermediate reduction products of nitro compounds. Sulphones, sulphonamides of secondary amines, sulphides, sulphates and other sulphur compounds. 

When the hicyclic lactam is substituted with a 3-hydroxypropyl group in the 6-position, acidic hydrolysis gives a bridged hicyclic acetal lactone (eq 6). ... 

Methyl 1-keto-l, 2,3,4-tetrahydrophenan-threne-2-acetate Lactone of 1-hydroxy-l, 2,3,4-tetrahydrophe-nanthrene-2-acetic acid D 80% 37... 

Allyiic halides, alcohols, ethers, acetates, lactones, phosphates, epoxides, sulfides, sulfonium salts, se-lenides and ammonium salts undergo transition metal catalyzed coupling reactions with C(sp )—Li, —Mg, —B, —Al, —Sn, —Zt, —Cd and — Hg reagents. Table 1 summarizes the allyiic leaving groups, alkenyl and aryl metallic reagents, catalytically active metals and references and Table 2 the regio- and stereo-chemical aspects. 

Ester 0 RC-OR Me-CO-OEth, ethyl acetate. Lactone cyclic ester, Triglycerides... 

Hasegawa Perf. Co. Tri- and tetra-Methyl-2-hydroxy-cyclohexylidene-acetic lactones. Japan. Kokai 75 069 062 (9. 6. 1975). 

The reactions of tosylate (38) with BF3 have been investigated in addition to the high-yielding reactions shown in Scheme 14, use of BF3 in dichloromethane gave a l,l 2.2 -dianhydro derivative of the furanose form, whilst the amide of the acid (38) rearranged to a 5-lactam similar to the acetal lactone (39).53... 

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