Thiofurodysinin acetate

The Australian nudibranch, Cerastoma brevicaudatum contained (methylthio)furodysinin (207) and dithiofurodysinin disulfide (208) [214], derivatives of thiofurodysinin acetate (209) that had been isolated earlier from a sponge [215]. Compounds 207 and 208 are also assumed to be of sponge origin. 

Two thioacetates, thiofurodysin acetate (320) and thiofurodysinin acetate (209) were isolated from a Dysidea species from Sydney, Australia. They were converted by treatment with Raney nickel to a mixture containing furodysin and furodysinin respectively [214], These were the first thiol acetates isolated from natural sources. The absolute configurations of (-)-(6/ ,ll/ )-thiofurodysinin acetate (209), (-)-(6/ ,ll/ )-furodysinin disulfide (208) and (+)-(6/ ,ll/ )-methoxythiofurodysinin acetate lactone (321), isolated from a Fijian specimen of D. herbacea were determined by chemical interconversion [292]. 

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