Acellular nerve allografts

Zhang, Y., Zhang, H., Zhang, G., Ka, K., Huang, W, 2014. Combining acellular nerve allografts with brain-derived neurotrophic factor transfected bone marrow mesenchymal stem cells restores sciatic nerve injury better than either intervention alone. Neural Regen. Res. 9, 1814-1819. 

Acellular nerve matrix allografts have also been observed as useful biomaterials for nerve regeneration [34]. These allografts preserve extracellular matrix (ECM) components and, therefore, mimic the ECM of peripheral nerves mechanically and physically. In this way, acellular nerve matrices aid in the reconstruction of the peripheral nerve. However, decellularization techniques, such as thermal deceUularization, can damage the ECM structure and fail to extract all cellular components leading to inflammation upon implantation [35]. 

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