Acceptable Minimum Detection Amount

Acceptable Minimum Detection Amount discussion, 102,103 See also Regulatory limits, process specifications Accuracy, definition, 149... 

Sensitivity by itself is not sufficient to completely evaluate an LCEC system for analytical purposes. The minimum detectable quantity (detection limit) is of more practical importance. The detection limit takes into consideration the amount of baseline noise as well as the response to the analyte. The detection limit is then defined as the quantity of analyte which gives a signal-to-noise ratio of three (a S/N of 3 is the generally accepted criterion although other values have been used). For a complete description of an LCEC application, both the sensitivity and detection limit, along with the S/N criteria used, should be provided. 

The minimum amount of radioactivity that can be detected by a flow-through radiochemical detector is a subject of continuing debate. It is generally accepted that a fairly sharp peak that contains counts that are at least twice background can be detected. One formula for calculating the minimum detectable activity (MDA) is given by... 

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