Acaricides pyrazoles

Pyrazole acaricides are derivatives of pyrazole. Tebufenpyrad is a broad-spectrum contact acaricide used for control of all stages of two-spotted spider mites and citrus red mites on cotton, fruits, vegetables, and ornamentals. It has an oral LD50 in rats of 595 mg/kg. Fenpy-roximate is an acaricide for control of important phytophagous mites on cotton, vegetables, fruit, vines, and others. 

Dihydro-2H-thieno[3,4-c]pyrazol-3-ylcarbamates show insecticidal, acaricidal and nematocidal activity. 

Fluoro- and flnoroalkylpyrazole templates are also present in important agrochemicals, two examples being the marketed fungicide penthiopyrad [96] (Fig. 7a) and the insecticidal anthranilic diamide (Fig. 7b) [97]. Fnstero and co-workers prepared a small set of analogues of the commercially available acaricide tebufen-pyrad with several fluorinated side chains at the pyrazole C-3 [98]. Some of these compounds displayed higher acaricidal activity than the parent compound tebufen-pyrad (Fig. 7c). 

Fustero S, Roman R, Sanz-Cervera JF, Sim6n-Fuentes A, Bueno J, ViUanova S (2008) Synthesis of new fluorinated tebufenpyrad analogs with acaricidal activity through regiose-lective pyrazole formation. J Org Chem 73 8545-85552... 

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