Neomycin Acarbose

Neomycin alone can reduce postprandial blood glucose levels and may enhance the reduction in postprandial glucose levels associated with acarbose. Neomycin 1 g three times daily increased the unpleasant gastrointestinal adverse effects (flatulence, cramps and diarrhoea) of acarbose 200 mg three times daily in 7 healthy subjects. The manufacturers suggest that if these adverse effects are severe the dosage of acarbose should be reduced." ... 

Neomycin Neomycin interferes with the absorption of digoxin, methotrexate, vitamins, some penicillins, acarbose, and oral contraceptives. 

Acarbose Acarbose interacts with other hypoglycemics and drugs that act on the GI tract. Neomycin and cholestyramine interact with acarbose. 

Neomycin may increase the efficacy and the gastrointestinal adverse effects of acarbose. There is some indirect evidence that acarbose with alcohol may increase the hepatotoxicity of paracetamol (acetaminophen). Parafytic ileus has been reported in a Japanese patient treated with acarbose and promethazine, an an-timuscarinic drug. 

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