Acanthodendrilla acanthosterol sulfate

An Acanthodendrilla sp. from Japan contained ten steroidal sulfates, acanthosterol sulfates A-J (561-570). Acanthosterol sulfates I (569) and J (570) showed antifungal activity against Saccharomyces cervisiae and its mutants [463]. Clathsterol (571), was isolated from the Red Sea sponge Clathria sp. The structure was established mainly by interpretation of spectral data and a chemical transformation. Clathsterol (571) was active against HIV-1 reverse transcriptase (RT) at a concentration of 10 iM [464]. Toxadocia zumi contains three sterol sulfates (572-574) that are antimicrobial, cytotoxic, ichthyotoxic and larvicidal [465]. 

Tsukamoto, S., Matsunaga, S., Fusetani, N and Van Soest, R.W.M. (1998) Acanthosterol sulfates A-J ten new antifungal steroidal sulfates from a marine sponge Acanthodendrilla sp. J. Nat. Prod., 61, 1374-1378. 

The main characteristic of sterols and sulfated sterols of sea stars is the preponderance of A7 sterols compared with AS sterols. The three best-known examples are A7 analogs of 24-nor-A22-cholesterol, occelasterol and gorgosterol -asterosterol, amuresterol and acanthasterol, respectively -whose names derive from the species in which they were discovered (stdfated acanthosterols were isolated from the sponge Acanthodendrilla sp. see Chapter 19). Experimental details of these three sterols are given by Schmitz (1978). 

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