Ac-globulin

Prothrombin activity (=source of thrombin) Ac-globulin activity 1 Proconvertin activity Activity corrective in haemophilia A Activity corrective in haemophilia B Activity corrective in haemophilia C Activity corrective in SPCA deficiency Activity corrective in Hageman trait... 

The next series of transformations leads to thrombin formation. A precursor of thrombin, the familiar prothrombin whose synthesis in the liver requires vitamin K, combines with thromboplastin stoichiometrically. The reaction requires calcium and a platelet factor referred to as platelet factor 1. The product of the reaction is thrombin but prothrombin production by the mechanism just described is so slow that the process must be activated for efficient coagulation, and thrombin catalyzes its own production. Thus, thrombin converts a plasma component, factor 1, or the plasma AC globulin into an active catalyst capable of accelerating prothrombin conversion to thrombin. 

Ac-globulin thrombogen factor V labile factor component A of prothrombin prothrombin accelerator proacce-lerin accelerator factor plasma prothrombin conversion factor plasmatic cofactor of thromboplastin prothrom-binase... 

In modern terminology the messenger RNA would collect the amino acid of peptides represented by A + B + C, etc., and deposit them on a ribosome where they would be assembled to give rise to A + C, or albumin AC, )3-globulin and various proportions of B + C in addition to A to give rise to a continuous system. A, B, and C are model peptides, but the system is not necessarily limited to these three, in that these three are not discrete peptides but rather areas on the template by this mechanism common peptides should appear in high incidence among the serum proteins. 

Proaccelerin Accelerator Globulin (Ac-G) V Factor V deficiency, (parahemophilia) Increased risk for thrombosis (Factor V Leiden) Extremely rare 7-10 0.025 Liver, megakaryocytes, endothelial cells 11-15 FA5 HUMAN... 

Most steroid hormones exist in part as sulfate esters and may also become esterified with fatty ac-ids. The fatty acid esters may have relatively long lives within tissues. A special sex hormone-binding globulin transports sex hormones in the blood and regulates their access to target cells. ... 

Globulins, Albumin and Plasma at Interfaces in "Applied Chemistry at Protein Interfaces", E. Baier Ed., Advances in Chemistry Series ACS Washington D.C. (1975). 

Farney AC, Doares W, Rogers J, Singh R, Hartmann E, Hart L, Ashcraft E, Reeves-Daniels A, Gautreaux M, Iskandar SS, Moore P, Adams PL, Stratta RJ. A randomized trial of alemtuzumab versus antithymocyte globulin induction in renal and pancreas transplantation. Transplant 2009 88(6) 810-9. 

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