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Nicotine abstinence effects

Bupropion is another alternative pharmacological approach to tobacco abstinence. It is an antidepressant drug that blocks reuptake of norepinephrine and dopamine, and also blocks nicotinic receptors in the low to intermediate micromolar range (Fryer and Lukas 1999). Thus, the effects of bupropion on nicotine addiction may be through dual effects on dopaminergic and nicotinic systems. Further, it has been an effective treatment in controlled studies, both alone and in combination with the nicotine patch. Bupropion alone or in combination with a nicotine patch was more effective than placebo or the nicotine patch alone. [Pg.117]

Pomerleau CS, Teuscher F, Goeters S, Pomerleau OF. (1994). Effects of nicotine abstinence and menstrual phase on task performance. Addict Behav. 19(4) 357-62. [Pg.486]

Kyerematen GA, Morgan M, Warner G, Martin LF, VeseU ES (1990) Metabohsm of nicotine by hepatocytes, Biochem Pharmacol 40(8) 1747-1756 Le Gal A, Dreano Y, Lucas D, Berthou F (2003) Diversity of selective environmental substrates for human cytochrome P450 2A6 alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine, Toxicol Lett 144(1) 77-91 Lee BL, Benowitz NL, Jacob P 3rd (1987) Influence of tobacco abstinence on the disposition kinetics and effects of nicotine, Clin Pharmacol Ther41(4) 474 79 Lee BL, Jacob P 3rd, Jarvik ME, Benowitz NL (1989) Food and nicotine metabolism, Pharmacol Biochem Behav 33(3) 621-625... [Pg.57]

A review of the evidence. Psychopharmacology 175 256-258 author reply 259-61 Perkins KA, Grobe JE, Weiss D, Fonte C, Caggiula A (1996) Nicotine preference in smokers as a function of smoking abstinence. Pharmacol Biochem Behav 55 257-263 Perkins KA, Sanders M, D Amico D, Wilson A (1997) Nicotine discrimination and selfadministration in humans as a function of smoking status. Psychopharmacology 131 361-370 Perkins KA, Sanders M, Fonte C, Wilson AS, White W, Stiller R, McNamara D (1999) Effects of central and peripheral nicotinic blockade on human nicotine discrimination. Psychopharmacology 142 158-164... [Pg.364]

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