Absorption Weibull-type

The typical absorption profiles are represented by the first-order absorption and the zero-order absorption. Atypical absorption profiles can be described by parallel first-order absorption, mixed first-order and zero order absorption, or Weibull-type absorption. 

The plasma drug profiles in 50 subjects, following oral administration of the drug X and assuming Weibull-type absorption, are plotted in Figure 13.6 (one Weibull function) and in Figure 13.7 (two Weibull functions). Corresponding NONMEM control files and data sets are in Appendix 13.5. 

FIGURE 13.6 Plot of simulated plasma concentrations of dmg X in 50 subjects, following a single oral dose, assuming a Weibull-type (one fnnction) absorption. Normal left panel) and semilog right panel) scale. Thick line represents popnlation predictions for a typical subject. 

APPENDIX 13.5 WEIBULL-TYPE ABSORPTION NONMEM Input for One Weibull Function... 

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