Absorption enhancers enteral drug delivery

For the last three decades, intensive research on the GI delivery of macromolecules has been conducted. Various approaches have been tested to promote the absorption of high MW drugs. One of the earliest strategies, which is still under investigation, is the use of surfactants. Surfactants have been demonstrated in numerous studies to efficiently enhance the enteral bioavailability of polypeptides, polysaccharides, and nucleotides. However, a major limiting factor in the application of these promoters is the potential toxicity of the surfactants... 

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