Absolute compliance

Note 2 The absolute compliance is related to the storage compliance (5.16) and the loss compliance (Definition 5.17) by the relationship... 

Note 3 The absolute compliance is the reciprocal of the absolute modulus. 

The tangent of the angle 5 is termed the loss factor. The amplitude ratio yQ/co = C is the absolute compliance. 

Absolute-, compliance with a defined target - eg a numerical Target Level of Safety (TLS) - or portion thereof Such criteria are usually quantitative ... 

Relative risk results show only the difference between the levels of safety of one or more cases of interest and a reference, or baseline, case. Relative risk estimates can be used (as can absolute estimates) to determine the most efficient way to improve safety at a facility. But, the use of relative risk estimates alone does little to help ensure that the most efficient way is safe enough unless one of the cases meets qualitative safety criteria (e.g., compliance with relevant codes, standards, and/or regulations consistency with current industry practice). 

The absolute minimum standard is compliance with all applicable codes and regulations in each jurisdiction we operate in. 

The duration of therapy is controversial and varies by continent. Europeans routinely treat patients for 7 days whereas Americans usually rely on a 14-day regimen. While this seven additional days of therapy improves the absolute cure rate by approximately 9%,14 longer courses decrease compliance and increase drug cost. 

Specifications are the requirements that include a quantifiable tolerance (e.g., Distance from inside bottom of the vessel and basket is 25 mm 2 mm or rotational speed 4%). Since these specifications are absolute it is fairly easy to assure compliance. 

Among the difficulties in pharmacological treatment is the frequent non-compliance. The biggest determinant of compliance is the quality of a patient s relationship with his doctor. But a further way to handle the issue has involved the development of long acting products (depot neuroleptics), even though their effectiveness in the absolute or compared to oral preparations has not been adequately explored. The most commonly used depot agents are fluphenazine and haloperidol decanoate (see David et al., 2004). 

If specified, the vendor shall test to demonstrate that the pump and its baseplate assembly, anchored at foundation bolt hole locations, are in compliance with 6.3.5. The pump casing shall be subjected to moments MTc and MZc applied to either nozzle, but not both, such that the corresponding shaft displacements can be measured and recorded. MYc and MZc shall not be applied simultaneously to either nozzle. The shaft displacement measurements shall be absolute (not relative to the baseplate). For record purposes, the vendor s test data shall include a schematic drawing of test set-up, the calculated moment loads 0/Fcand MZc), and the applied moment loads and their corresponding displacements at the drive end of the pump shaft. 

Figure 15. Shift factors, log a , for extra compliance of Kraton 102 cast from benzene solution, plotted against the reciprocal of absolute temperature...

When corrective and preventative actions are consistently minimalist and not concise, the results will eventually be reflected in product quality and in the firm s compliance status. Additionally, many problem, can arise when corrective and preventative actions are installed and presumed to be absolute without a short-and long-term assessment of the action. It is important not to assume that the CAPA installed today is necessarily the best practice or solution over the long haul. A long-term review of the CAPA will be the best indicator of its long-term viability. 

A summary statistic, such as how often the limit may be exceeded (e.g., 5% of the time or on 5% of the monitoring events). This point excludes the absolute limit because compliance and planning for such standards can only be... 

Absolute limits cannot be used in statistical assessments of compliance based on sampling such standards need to be translated into percentiles to be used. The reasons for this are that standards are usually set in a precautionary manner, and it is nearly always the case that occasional exceedances of a limit value are acceptable. With such an absolute limit, the risk of reporting failure is strongly influenced by sampling frequency the more sampling, the higher the likelihood that at least 1 sample will fail. This is an important consideration if compliance assessments are to be used to compare regions or nations in a way that has serious implications for poor performers. 

An additional problem lies in setting up the action to secure compliance. An absolute limit must never be exceeded, but what is meant by never Once in a million years The answer to this question defines the absolute limit as a percentile it expresses the proportion of time for which failure is acceptable. This is also the outcome when we select a sampling frequency. There are 31 million seconds in a year, and we might sample 12 of them. This leaves a lot of time when we might fail the absolute limit and not notice it, and this accepted proportion of time defines the percentile Twelve samples a year treats an absolute limit as something like an annual 95th percentile. 

Although the decision associated with the application of a standard is a decision with a pass or fail value, the application of a standard implies recognition of uncertainty underlying its derivation and in the assessment of compliance. The exceedance of a speed limit by a few miles per hour does not usually lead to prosecution. This may be because the standard is precautionary or because the measuring device is not 100% accurate. The police might choose to act only when the limit is exceeded by, say, 10%, a policy that reflects issues of confidence and precision and the consequences of the violation in terms of the risk of accidents. At greater exceedances of the speed limit, more serious consequences for the offender are likely therefore, the absolute limit value of the speed limit is not necessarily implemented as an absolute limit that if exceeded will result in equivalent consequences. 

For environmental standards, a strict analogy with speed limits can be misleading because the speed limit is an absolute limit, and the driver can secure compliance by driving everywhere just below the limit. In environmental decisions, the situation is more like the case of a new kind of vehicle that needs no driver and whose speed varies randomly and uncontrollably. How should the car be designed so that the speed limit is never exceeded and so that we could check for compliance by observing it, say, once a month ... 

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