A ruthenium-catalyzed hydrogenation

The enantioseiective hydrogenation of a-amino ketones has been applied extensively to the synthesis of chiral drugs such as the / -agonist SR 58611 (Sanofi Cie). m-Chlorstyreneoxide was obtained via carbene-induced ring closure of the amino alcohol. Epoxide-opening by a chiral amine obtained via a ruthenium-catalyzed hydrogenation of an enamide has led to the desired compound where... 

In 2009, the group of Tulchinsky at Dow claimed the synthesis of several aliphatic sulfonated phosphines [95]. The key reaction in Scheme 2.29 is a ruthenium-catalyzed hydrogenation of an oxidized P-phenylsulfonate unit. 

Historically, this term was applied for the first time by Noyori [2], in the case of a ruthenium-catalyzed hydrogenation of a-substituted-P-keto esters. According to Noyori and his coworkers, even when the racemization constant k ac is the same as the rate constant of the fast reacting enantiomer, good enantioselectivities and quantitative conversions can be obtained [3]. An efficient DKR process can also be obtained when krac is higher than the rate constant of the reduction of the slow reacting enantiomer (krac > fesiow)-... 

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