A Practice Tutorial for Homology Modelling

There are many commercial and free software through which modelling can be done. Modeller is a free tool for comparative modelling including loop modelling some commercial GUI-based versions are also available [31]. We demonstrate an 

5 Active Site-Directed Pose Prediction Programs for Efficient. 

open the MOE window by double clicking the icoa Go to file open and browse the sequence in fasta format in to the sequence viewer. Click on the SEQ button present at the upside right comer of the MOE window as shown in figure. It opens the sequence viewer window (Fig. 5.27). 

go to the display option in the sequence editor window and check the compound name and single-letter residues boxes. This will display the name of the sequence and the single-letter representation of the sequence (Fig. 5.28). 

It is known that the next step is to search for a similar sequence for which a crystallized stractnre is available. For this, we have the PDB search option in MOE (similar to performing Basic Local Alignment Search Tool (BLAST)). Go to homology PDB search (Fig. 5.29). 

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A Practice Tutorial for Homology Modelling Fig. 5.22 Volume of first site... 

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