A Potential Role of RORs in Xeno- and Endobiotic Gene Regulation

Inflammation Anti-inflammation (suppression of NF-kB activity by activating Ikk 3) [34, 39,40,41,46] [Pg.305]

Circadian rhythm A crucial component of the molecular circadian clock (regulating the clock gene BMALI) [42] [Pg.305]

Osteoporosis Protection against osteoporosis (regulating bone sialoglycoprotein and osteocalcin) [43, 45] [Pg.305]

Metabolic homeostasis Regulation of triglyceride and lipoprotein metabolism and protection against atherosclerosis (regulating ApoAI and ApoCIB) [49, 50] [Pg.305]

Xenosensor Positive and negative regulation of phase I and phase II drug-metabolizing enzymes [51,52] [Pg.305]

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