A-Piperidino

For preparation of dipolar polymers with dielectric properties and nonlinear optical applications, a piperidino-substituted a-cyanocinnamic acid was polycondensed with CDI.[551,tl54]... 

An orchestrated six-step reaction sequence using seven different supported reagents has been described for the synthesis of a piperidino-thiomorpholine Hbrary... 

The reaction of JV-(j8-chloroethyl)piperidine or its derivatives with methanolic potassium hydroxide89 yields Hofmann degradation products27 (mainly 1,2-bis(A-piperidino)ethane) of 1,4-bispenta-methylenepiperazinium dichloride which is evidently the initial product rather than quinuclidine compounds. 

The sp3 - sp2 hybridization change is shown by similar examples to be more facile for a dimethylamino nitrogen than for a piperidino nitrogen. Thus, the poorer A-basicity of compound 4 relative to 2 is apparently more than balanced by a relative lack of conformational problems upon rehybridization. 

The triaminocyclopropenium ion is also allowed to react with potassium cyanide at room temperature to give a novel product which can be different depending on whether the substituent Y is an aromatic amino group or an aliphatic amino group, If Y is an aromatic amino group, we get the product (20) in 80% yield, whereas if Y is aliphatic, for instance a piperidino group, we get the product (27) in 10% 5deld. 

Four moles of periodate were required for the oxidation of 1-deoxy-l-piperidino-D-fructose and I-deoxy-I-morpholino-D-fructose at pH 4.5. As indicated, one mole of these compounds would be expected to consume four moles of oxidant to produce a-piperidino- or a-morpholino-acetic acid, three moles of formic acid, and one mole of formaldehyde. Although the acid titration showed that three moles of acid were formed, the presence... 

Further preparations were the oxidation of 2-methyl-3-piperidinopyrazine with hydrogen peroxide in acetic or formic acid to 3-methyl-2-piperidinopyrazine 1-oxide and 2-(7V -hydroxy-7V -piperidinio)-3-methylpyrazine hydroxide (51) [which was dehydrated by sublimation to 2-methyl-3-(A -piperidino-7V -oxide)pyrazine... 

Carbamoylpyrazines have been hydroxymethylated with formaldehyde and potassium carbonate, and aminomethylated with formaldehyde and amine. In this way the following have been prepared 2-Af-hydroxymethylcarbamoylpyrazine (138) 2W-(diethylaminomethyl)carbamoylpyrazine (1413-1416) 2W-(morpho-linomethyl)carbamoylpyrazine (1414, 1416) and 2-A -[piperidino(pyrrolidino or other amino)methyl]carbamoylpyrazines(1414,1416). 2-7V-(Diethylaminomethyl)-carbamoylpyrazine refluxed with morpholine afforded 2-A -(morpholinomethyl)-carbamoylpyrazine (1415), and 2-carbamoylpyrazine with TV-(morpholinomethyl)-benzenesulfonamide gave 2-7V-(morpholinomethyl)carbamoylpyrazine (1417). 

DW 75 pentacosactride. dyclocaine [ban] (dyclonine [inn] dyclonine hydrochloride [usan) Dyclone ) is a piperidino-propiophenone, with antiarrhythmic and local ANAESTHETIC properties. It is used by topical application, including to mucous membranes, for local pain relief, dyclonine hydrochloride dyclocaine. dyclonine dyclocaine. 

An 0-silylated cyclopropanone A,0-acetal is best used as starting material for the transfer of the parent 1-aminocyclopropyl group to C-H acids to give A piperidino group, rather... 

S-A-[2,3,5,6-Tetrafluoro-4-(A -piperidino)-phenyl]-A-allyloxycarbonylaminomethyl Thioether (Fnam-SR)... 

The reactions of perchlorotoluene and perchloro-p-xylene with piperidine are analogous to the basic hydrolysis in DMSO (Ballester et ai, 1967). Nevertheless, some substitution of the a-chlorines by a piperidino group occurs. The reaction of perchlorotoluene with piperidine (34) gives [51], [52] and the piperidino compound [53], which results from the latter by nucleophilic displacement of the a-chlorine (M. Ballester and C. Carreras, unpublished). The reaction of perchloro-/>-xylene with piperidine takes place with... 

SR 141716A - A-Piperidino-5-(5-chlorophenyl)-1 -(2,4-dichlorophenyl) -meihyl-3-pyrazole-... 

In the case of Af-(2,4-dinitrophenyl)piperidine, Af-(2,4-dinitrophenyl)morpholine , Af-(2,4,6-trinitrophenyl)piperidine and Af-(2,4,6-trinitrophenyl)morpholine the amino group is the leaving group with hydroxide ions, as shown by reaction 26. L (the leaving group) may be an A -piperidino or an A -morpholino group. These reactions are complicated by the formation of a adducts in the unsubstituted positions of the phenyl ring. 

N-[ -Aoetoxy-prapyl]-pip idm 20, 27. a-Piperidino-propioiisfiiiTe-athyleeta 20. 62. d-Piperidino-propioiiafiure-athylester 20, 62, 1138. 

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