A New General Method for the Preparation of Weinreb Amides from Esters

A New General Method for the Preparation of Weinreb Amides from Esters 

The reaction of an ester with Weinreb amine and i-PrMgCl provides a general method for the preparation of Weinreb amides that has been widely used in the 

4) Broader utility has been realized since the publication of our work. 

The list of Process Chemists, Chemical Engineers, and Analytical Chemists who contributed to the success of this effort is too long to include here. I would, however, like to acknowledge the contribution of Apu Bhattacharya in discovering the silylation-mediated dehydrogenation of the azasteroids and Ulf Dolling whose guidance made our success possible. 

3318-3319. For reactions of quinones where adducts were also observed see. (b) Becker, H.-D. (1965) 

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