A-methiodides

Base Z, C12H21O2N. This name was provisionally applied to a syrupy base which yielded a crystalline oxalate, B2. H2C2O4, m.p. 296-7°, a hydrobromide m.p. 219-20° 2-9° (c = 6 H2O), a methiodide... 

Papaveraldine (Xanthaline), C2oHij05N. This substance forms colourless scales, m.p. 210°, yields well-crystallised yellow salts, which are dissociated in water, and reacts as a tertiary base, forming a methiodide, m.p. 133-5°. It gives an oxime existing in two stereoisomeric forms, and contains foru methoxyl groups. The demethylated product, papaveraldoline, Ci0H,ON(OH)4, has been prepared by Oberlin. Miss Dobson and W. H. Perkin have shown that the alkaloid, Xanthaline, isolated from opium by T. and H. Smith, is identical with papaveraldine. On reduetion with... 

Tuduranine, CjgHjgOgN. This member of the aporphine group (p. 306) is the most recent addition to Sinomenium alkaloids and was isolated by Goto from the mother liquors of sinomenine. It is crystalline, has m.p. 125° (with softening at 105°), and yields a sparingly soluble hydrochloride, m.p. 286° (dec.), [a] f — 148° (dilute MeOH), is freely soluble in alkali, and gives feeble ferric chloride and diazo-colour reactions and a fuchsin-red colour with formaldehyde and sulphuric acid. It behaves as a secondary base and yields a diacetyl derivative, m.p. 170°, [a] / — 321-71° (MeOH), which does not form a methiodide, but can be hydrolysed to A -acetyl-tuduranine, m.p. 277°, — 395-24°, and this can be methylated to... 

Oripavine, CigHjiOgN (Item 56 list, p. 173). Tliis alkaloid was isolated by extracting the dried leaves, moistened with ammonia, with ethylene dichloride. It crystallises from alcohol in colourless needles, has m.p. 200-1°, [a]o — 211-8° (CHCI3), yields a hydrochloride, m.p. 244-5°, and a methiodide, m.p. 207-8°. The base is soluble in sodium hydroxide solution, giving a crystalline sodium derivative. It contains one hydroxyl, one methoxyl and one methylimiiio group. 

Fioribundine, C gHjgOgN, crystallises from acetone in prisms, has m.p. 193-5°, [a]n— 204-28° (CHCI3), and gives a tartrate, m.p. 181-3°, and a methiodide, m.p. 178-80°. One methoxyl and one methylimino-group are present. The mother liquors from fioribundine appear to contain a fifth alkaloid, m.p. 200-3°. 

Eximidine, Ci,Hj40N(0Me)3. (Item 36 list, p. 172.) A phenolic base, m.p. 133°, yielding a methiodide, m.p. 218° (dec.). It is isomeric with corydine and possibly belongs to the aporphine group (Manske). ... 

EtOH). No methoxyl is present. It forms a series of crystalline double chlorides with cadmium, zinc or copper, does not give the thalleioquin reaction, and solutions of its sulphate are not fluorescent. It is diacidie and forms two series of salts of which the nitrate, B. HNOj, crystallises in minute prisms, m.p. 196°, insoluble in water. Cinchonamine hydrochloride, B. HCl, laminae or B. HCl. HjO, cubical crystals, has been suggested for use in the estimation of nitrates. When warmed with strong nitric acid the alkaloid furnishes dinitrocinchonamine. It gives an amorphous, monoacetyl derivative, and forms a methiodide, m.p. 208 , which with silver oxide yields an amorphous methylcinchonamine. Raymond-Hamet found that cinchonamine ves typical indole colour reactions and is probably an indole alkaloid. This seems to have been... 

Gramine forms flat needles or leaflets, m.p. 138-9°, [a]p 0°, and yields a pierate, m.p. 144-5°, perehlorate, m.p. 150-1° platiniehloride, red needles, m.p. 180-1° dec.) and a methiodide, m.p. 176-7°. Aeeording to Madinaveitia, gramine on treatment with methyl iodide in methyl aleohol yields trimethylamine, tetramethylammonium iodide and a substanee presumed to be 3-hydroxymethylindole. With ethyl iodide in acetone a normal ethiodide, CiaH gNjI, m.p. 176°, is formed. 

Harmine, C13H12ON2, crystallises from methyl alcohol in colourless rhombic prisms, m.p, 266°, [a]D 0°. The hydrochloride, m.p. 269-5-270-5° (Chen ), nitrate, platinichloride, m.p. 264-6°, acid chromate and oxalate crystallise well. The salts show a deep blue fluorescence in dilute solution. Harmine behaves as a monoacidic base. It gives a methiodide, from which methylharmine, needles, m.p. 209°, may be prepared, and this in turn yields methylharmine methiodide. On demethylation harmine yields the phenolic base harmol, C12H10ON2, m.p. 321°.i ... 

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