A Defined Endpoint

Some examples of widely modelled end-points are reported. Several alternative models of BCF (an important parameter in environmental assessment as it is an estimate of the tendency of a chemical to concentrate and, consequently, to accumulate in an organism) have been developed some are based 

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In a systematic search there is a defined endpoint to the procedure, which is reached whe all possible combinations of bond rotations have been considered. In a random search, ther is no natural endpoint one can never be absolutely sure that all of the minimum energ conformations have been found. The usual strategy is to generate conformations until n new structures can be obtained. This usually requires each structure to be generate many times and so the random methods inevitably explore each region of the conformc tional space a large number of times. 

When and how should a medication be discontinued A plan for discontinuing medication should be established when therapy is initiated. At the conclusion of the planned treatment period, it is appropriate to re-evaluate the patient and to decide if the initial criteria for dmg efficacy have been met. Ideally, the patient s condition should have reached a defined endpoint, such as resolution of symptoms in acute disease processes, or return to baseline staffis in a chronic illness. Some dmgs, such as anticonvulsants, steroids, and some antidepressants, require a plan for tapering doses and gradual weaning to avoid exacerbation of the disease. 

Must have a defined endpoint This is to ensure clarity and identify the experimental system that is being modeled by the (Q)SAR. 

A defined endpoint. A (Q)SAR should be associated with a defined endpoint , which refers to any physicochemical, biological, or environmental effect. The intent of this principle is to ensure transparency of the modeled data. 

On the basis of experience to date, the Steering Committee has outlined a stepwise ICH process (Figure 16.1) for monitoring the progress of the harmonisation work and identifying the action needed in order to reach a defined endpoint. 

A defined endpoint. An independent variable, which is used for modeling has to be well defined ... 

Principle 1 a defined endpoint biological activity, then generalized to the final product rate in the ligand-receptor interaction, as based on the Michaelis-Menten enz34ne-substrate kinetics ... 

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