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A Chemical Genomics Approach for Ion Channel Modulators

The physiological effects of ion channels are based on the regulation of ion fluxes (e.g., K+, Na+, Ca2+, Cl-) across membranes, which affect, for example, osmotic pressure, nerve signal transmission, and muscle contraction. Ion permeation is extremely fast (up to 107 ions s-1) and highly selective [1], [Pg.221]

Calcium-channel blockers are used for treating cardiac arrhythmia and pulmonary hypertension and for prevention of reperfusion injury. Sodium channels have been linked to epilepsy and hyperkalemic periodic paralysis (Table 8.1). [Pg.222]

Nimodipine was approved in August 2000 for the improvement of neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage. [Pg.222]

The sodium-channel inhibitor Amiloride is used for the treatment of chronic bronchitis, and the most frequently used anesthetic drug, lidocain, inhibits voltagegated sodium-channel a subunits, which mediate the pathophysiology of pain. [Pg.222]

Calcium channels Arrhythmia, diabetes, epilepsy, hypertension, migraine, stroke [Pg.222]

See other pages where A Chemical Genomics Approach for Ion Channel Modulators is mentioned: [Pg.221]    [Pg.222]    [Pg.224]    [Pg.226]    [Pg.228]    [Pg.230]    [Pg.232]    [Pg.234]    [Pg.236]    [Pg.238]    [Pg.239]    [Pg.240]    [Pg.242]    [Pg.221]    [Pg.222]    [Pg.224]    [Pg.226]    [Pg.228]    [Pg.230]    [Pg.232]    [Pg.234]    [Pg.236]    [Pg.238]    [Pg.239]    [Pg.240]    [Pg.242]    [Pg.222]    [Pg.418]   


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Channels a

Chemical approaches

Chemical channels

Chemical modulation

Genomic approach

Genomics Approaches

Ion approach

Ion channel modulators

Ion modulator

Ion modulators

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