A and Insulin Sensitivity

Amount of CLA (g/day) Fomn of CLA Placebo Duration Subjects Effect of CLA Reference 

4 50 50 c/s-9,frans-11 and frans-10,c/s-12 CLA vs. frans-10.cis-12 Olive oil 12 wks 60 abdominally obese males with signs of the metabolic syndrome aqe 35-65 y t10,c12 CLA decreased insulin sensitivity (assessed bv IVGTT). Riserus ef a/. 2002a 

3 ds-9,trans-11 CLA Olive oil 12 wks 25 abdominally obese males age 35-65 y c9,t11 CLA decreased the insulin sensitivity index. Riserus ef a/. 2004 

3 50 50 c/s-9,frans-11 and trans-10,c/s-12 CLA Palm oil + soybean oil 8 wks 32 type 2 diabetics CLA increased plasma glucose, increased HOMA, and decreased the insulin sensitivity index relative to control. However, there were differences between control and CLA before treatment. Moloney ef at. 2004 

38 (c/s-9,frans-11) 0.63, 1.26, 2.52 transA Q,cis 2) c/s-9, frans-11 vs. trans-10,c/s12 None (cross- over design) 8 wks on each dose (doses increased sequen-tiaiiy 6 wk washout between isomers) 49 healthy males age 20-47 y Increased fosting glucose, but no effects on insulin, insulin resistance (HOMA), or insulin sensitivity (revised QUICKI). Tricon ef al. 2004 

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