A-Acylaminonitriles

A Reissert compound has been prepared from 9-methoxyellipticine and both it and 10 give a fluoroborate salt of the type 19. The Reissert compound of 6,7-dimethoxyphthalazine has been used to prepare an azapa-paverine. The oxoaporphine alkaloid subsessiline has been synthesized using the Reissert compound of 5,6,7-trimethoxyisoquinoline. The reaction of vanillin Schiff bases with benzoyl cyanide yields open-chain analogs of Reissert compounds. a-Acylaminonitriles, which can be considered as open-chain Reissert compounds, have been converted to open-chain analogs of Reissert salts (5-imino-3,5-dihydrooxazole derivatives). - ... 

Ultraviolet absorption spectroscopy has been used to determine isomeric product ratios,101 to estimate the position of the thione-thiol equilibrium in oxazoline-2 (3/1 )-thiones,246 to study the mechanism of the isomerization of 5-aminooxazoles to a-acylaminonitriles,244 and also for the quantitative determination of 4-methyl-5-propoxyoxazole.246 Berlman,247 from a study of emission spectrograms, has shown that transient excited dimers are formed by concentrated solutions of 2,5-diphenyloxazole in p-xylene. 

Controlled hydrolysis of a-acylaminonitriles Carboxylic acids and carboxylic acid amides from nitriles... 

Functional group replacement by cyano is an important synthetic transformation since it frequently allows homologation by hydrolysis to the carboxylic acid, or by reduction to an amine. The replacement of sulphinyl by cyano via trimethyl-silylcyanide thus provides a preparation of aliphatic cyanomethyl ethers, and this useful reagent has been further employed to provide cyclic a-acylaminonitriles by the replacement of methoxy-groups. The replacement of a primary amino-group by cyano is an often sought after transformation, and... 

Phosphoric acid a-Aminocarboxylic acids from a-acylaminonitriles... 

Acylaminomethylation s. a. Imidomethylation N-Acylaminomethylation 23, 760 a-Acylaminonitriles racemization 23, 744 0 Acy iamino-an t i-oximes... 

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