A-Acetylglucosaminidase

Altmann, F., Schwihla, H., Staudacher, E., Glossl,J. and Marz, L. (1995) Insect cells contain an unusual, membrane-bound P-A-acetylglucosaminidase probably involved in the processing of protein Atglycans. Journal of Biological Chemistry 270,17344-17349. 

Conklyn, M. J., Kadin, S. B., and Showell,H. J. (1990) Inhibition of IgE-mediated A-acetylglucosaminidase and serotonin release from rat basophilic leukemia cells (RBL-2H3) by Tenidap A novel anti- inflammatory agent. Int. Arch. Allerg. Appl. Immunol. 91, 369-373. 

This enzyme [EC 3.2.1.14] (also referred to as chitodex-trinase, l,4-j8-poly-A-acetylglucosaminidase, and poly-j8-glucosaminidase) catalyzes the hydrolysis of the l,4-j8-linkages of A-acetyl-D-glucosamine polymers of chitin. It should be noted that some chitinases will also display the activity observed with lysozyme [EC 3.2.1.17]. 

Because of the importance of protein O-A-acetylglucosaminidases (EC 3.2.1.169) which are P-A-acetylghicosaminidases and that catalyze the cleavage of P-linked A-acetyl-D-ghicosaminides with serine and threonine residues of many eukaryotic... 

Takegawa K, Yamaguchi S, Kondo A, Iwamoto H, Nakoshi M, Kato 1, Iwahara S. Transglycosylation activity of endo-beta-A-acetylglucosaminidase from Arthrobacter protophormiae. Biochem. Int. 1991 24 849-855. 

Numerous urinary enzymes such as A-acetylglucosaminidase (NAG), alanine aminopeptidase (AAP), alkaline phosphatase (AP),... 

Fig. 3. Biosynthesis of Man-6-P N-linked oligosaccharides and interaction with Man-6-P receptors. This figure compares the biosynthetic pathways of Man-6-P on lysosomal enzymes in mammalian cells and in Dictyostelium discoideum. It also shows their binding to the cation-independent/insulin-like growth factor II receptor (Man-6-P/IGFII) and to the cation-dependent mammalian Man-6-P receptor. Enzymes are (1) GlcNAc-1-P transferase, (2) a-A-acetylglucosaminidase, and (3) M-6-P phosphate methyltransferase. Solid circles, Man solid squares, GlcNAc.

Hunter Hurler + Scheie Maroteaux-Lamy Mucolipidosis Vli Sanfilippo A Sanfilippo B Sanfilippo D iduronate suifatase a-L-iduronidase A/-Acetylgalactosamine suifatase p-Glucuronidase Heparan sulfamidase A/-Acetylglucosaminidase A/-Acetylglucosamine 6-sulfatase Heparan sulfate. Dermatan sulfate Heparan sulfate. Dermatan sulfate Dermatan sulfate Heparan sulfate. Dermatan sulfate Heparan sulfate Heparan sulfate Heparin sulfate... 

Imada et al. reported the isolation of pyrostatins A and B from culture broth of strain Streptomyces sp. SA-3501 isolated from a marine sediment [19,20]. The structures were determined as 2-iminopyrrolidine carboxylic acid derivatives 7-8. These compounds showed specific inhibitory activity against A-acetylglucosaminidase but no antimicrobial activity. 

Tai, T., Yamashita, K. Kobata, A. (1977a) The Substrate Specificities of Endo-P-A/-acetylglucosaminidases Cn and H , Biochemical and Biophysical Research Communications, 78, 434-41... 

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