A- acetophenones

Fig. 8 Capillary EKC separations of (A) acetophenone (1), propiophenone (2), butyrophenone (3), valerophenone (4), and hexanophenone (5) on vesicles composed of sodium dodecylsulfate and ra-dodecyltrimethylammoniumbromide at pH 7.2, (B,C) of 1-dehydroaldosterone (1), cortisone (2), cortisol (3), 21-deoxycortisol (4), 11-deoxycortisol (5), and dexamethasone (6) on liposomes composed of 1-palmitoyl-2-oleoyl-sra-glycero-3-phosphocholine (80%) and (B) phosphatidylserine or (C) car-diolipin at pH 9, lipid concentrations (B) 2.4 mM and 0.6 mM, (C) 3.6 and 0.9 mM. (Part A is reprinted with permission from Ref. 59, copyright 1998 American Chemical Society Parts B and C are reprinted with permission from Ref. 33, copyright 2000 Wiley-VCH Verlag, all with slight modifications.)...

Figure 8 Guest-dependent polymorphism in CA inclusion crystals with (a) acetophenone, (b) y-valerolactone, (c) ethynylbenzene, (d) 2-fluoropropiophenone, (e) m-chloroaniline, (f) water (Form I), (g) water (Form II), (h) 3-methylcyclohexanone, (i) acetic acid, (j) m-fluoroaniline, (k) 1,2,3-trimethylbenzene, and (1) acrylonitrile. Hydrogen atoms are omitted for clarity. Carbon, nitrogen and oxygen atoms are represented by open, gray and tilled circles, respectively. 

Complex 1 also catalyzes the regioselective radical addition of perhalogeno-ethanes to silyl enol ethers. The primary addition-desilylation products undergo the facile /1-elimination of a chloride to afford a,/3-unsaturated ketones [26, 27]. For example, CF2C1CC13 adds to the trimethylsilyl enol ether of acetophenone to yield /i-chloro-/i-(chlorodifluoromethyl)-a,/ -acetophenone in 80% yield (Eq. 9). 

Show how Friedel-Crafts acylation might be used to synthesize the following compounds, (a) acetophenone (b) benzophenone (c) n-butylbenzene... 

A. Acetophenone N,N-dimethylhydrazone. A mixture of acetophenone (12.0 g., 0.1 mole), anhydrous N,N-dimethyl-hydrazine (18.0 g., 0.3 mole) (Note 1), absolute ethanol (25 ml.) and glacial acetic acid (1 ml.) (Note 2) is heated at reflux for 24 hours. During this period the colorless solution becomes bright yellow. The volatile reactants and solvent are removed under reduced pressure. The residual oil is fractionally distilled through a 10-cm. Vigreux column to give a small forerun of unreacted acetophenone, b.p. 30-40° (0.15 mm.), followed by 14.6-15.2 g. (90-94%) of acetophenone N,N-dimethylhydra-zone, b.p. 55-56° (0.15 mm.), n25d 1.5443 (Notes 3 and 4). 

A Acetophenone derivatives can be prepared from benzene by a Friedel-Crafls acylation. The derived oxime, formed using hydrox-yiamine, undergoes a Beckmann rearrangement to produce the... 

Organon have developed Org 31710 and Org 33628 (Figure 7.2). Org 31710 has the same substituent at position 11 but differs at the 17-position, where it contains a spiro-ether group. In the B-ring, it has a 6P-methyl group. Org 33628 has a acetophenone group instead of a dimethylaminophenyl group and is combined with a methylene-furan substituent at position 17 [12]. 

Draw the product of the base-catalyzed aldol reaction of each compound (a) Acetophenone (b) Cydopentanone... 

Figure 4. Reciprocal reduced volume as a function of the volume percentage of polymer for nonaqueous suspensions A, DMF O, benzonitrile , cyclohexanone A, acetophenone O, 1,4-dioxane V, methyl benzoate , ethyl acetate O, benzyl alcohol, D =...

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