A2B-Adrenergic receptors

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Cussac D, Schaak S, Gales C, Flordellis C, Denis C, Paris H (2001) a2B-adrenergic receptors activate MAPK and modulate the proliferation of primary cultured proximal tubule cells. Am J Physiol Renal Physiol 8 8... 

Kintsurashvili E, Gavras I, Johns C, Gavras H (2001) Effects of antisense oligodeoxynucleotide targeting of the a2B -adrenergic receptor messenger RNA in the central nervous system. Hypertension 38 1075-80... 

Bylund DB, Ray-Prenger C, Murphy TJ. a2A and a2B adrenergic receptor subtypes antagonist binding in tissues and cell lines containing only one subtype. J Pharmacol Exp Ther 1988 245 600-607. 

Zeng D, Harrison JK, D Angelo DD, et al. Molecular characterization of a rat a2B-adrenergic receptor. Proc Natl Acad Sci USA 1990 87 3102-3106. 

Saunders C, Limbird LE. Microtubule-dependent regulation of a2B adrenergic receptors in polarized MDCKII cells requires the third intracellular loop but not G protein coupling. Mol Pharmacol 2000 57 44-52. 

Brady AE, Wang Q, Colbran RJ, Allen PB, GreengardP, LimbirdLE. Spinophilin stabilizes cell surface expression of a2B-adrenergic receptors. J Biol Chem 2003 278 32,405-32,412. 

Snapir A, Heinonen P, Tuomainen TP, et al. An insertion/deletion polymorphism in the a2B-adrenergic receptor gene is a novel genetic risk factor for acute coronary events. J Am Coll Cardiol 2001 37 1516-1522. 

Huang L, Wei YY, Momose-Hotokezaka A, Dickey J, Okusa MD. a2B-Adrenergic receptors immunolocalization and regulation by potassium depletion in rat kidney. Am J Physiol 1996 270 F1015-F1026. 

The a2B-Adrenergic Receptor Null Mice Reveal Roles for the a2B-AR Subtype in Hypertension, Antinociception to Nitrous Oxide, and Development 3.1. The a2B-AR in Blood Pressure Regulation... 

Kintsurashvili E, Johns C, Ignjacev I, Gavras I, Gavras H. Central a2B-adrenergic receptor antisense in plasmid vector prolongs reversal of salt-dependent hypertension. J Hypertens 2003 21 961-967. 

Small KM, Brown KM, Forbes SL, Liggett SB. Polymorphic deletion of three intracellular acidic residues of the a2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. J Biol Chem 2001 276 4917-4922. 

Figure 8 Altered agonist-promoted phosphorylation and desensitization of the Del301-303 a2B-adrenergic receptor polymorphism in transfected cells.

Baldwin CT, Schwartz F, Baima J, Burzstyn M, DeStefano AL, et al. 1999. Identification of a polymorphic glutamic acid stretch in the a2B-adrenergic receptor and lack of linkage with essential hypertension. Am. J. Hypertens. 12 853— 57... 

Heinonen P, Koulu M, Pesonen U, Karvonen MK, Rissanen A, et al. 1999. Identification of a three-amino acid deletion in the a2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. J. Clin. Endocrinol. Metab. 84 2429-33... 

Fig. 8.1 Sequence alignment of the four hARs (A, A2a, A, A3), bovine rhodopsin, hp2 adrenergic receptor, and turkey pj adrenergic receptor. In grey are highlighted the transmembrane regions, in red the highly conserved residues and in yellow cysteines that form disulfide linkages that involve EL2. For Ar A2B, AjARs only the cysteine residues that form the conserved disulfide bridge between TM3 and EL2 are highlighted in yellow, because information about other disulfide bonds is not available...

In the case of the p2-adrenergic receptor, phosphorylation of serine and threonine residues in the carboxyl tail can be shown to be involved in desensitization and internalization [156, 171]. Other GPCRs—such as the p- and 6-opioid receptors [172, 173] and the A2b adenosine receptor [174]—require analogous serine and threonine residues in the carboxyl tail for both desensitization and internalization [172, 173],... 

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