99mrpc

The kit contains the lyophilized, sterile ingredients in a multidose vial. Labeling with 99mrpc-pertechnetate is carried out under aseptic conditions by adding a suitable volume of sterile Tc eluate, up to 3.7 GBq (100 mCi) to the reaction vial. The reaction is allowed to proceed at room temperature for 20 min. Tc-tin colloid is a sterile, pyrogen-free, opalescent solution suitable for intravenous injection. The pH is 4.0-6.0 on pH paper. 

A special formulation of medronate (Amerscan Stannous Agent) is used for in vivo loading of red blood cells with stannous ion, preparatory to labeling with sodium 99mrpc-pertechnetate. 

Pentavalent Tc(V)-DMSA differs structurally and has been evaluated for imaging medullary carcinoma of the thyroid (Ohta et al. 1984 Ramamoorthy et al. 1987). The sensitivity of lesion detection is 95% no false positive uptake of Tc(V)-DMSA was seen in nine patients with a histologic diagnosis of medullary carcinoma. Accumulation of Tc(V)-DMSA was seen in both bone and soft tissue metastases. In comparison, 99mrpc-MDP detected all known metastases in bone, but none in soft tissue (Clarke et al. 1988). 

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