8a-Estrone

Under similar conditions totally synthetic 8a-estrone and c t-8a-estrone give 17a-ethynyl-8a-estradiol in 45% yield and the enantiomeric derivative in 84% yield. ... 

Hydroxy-8a-estra-l,3,5(10)-trien-17-one (8a-Estrone, 3) Typical Procedure92 ... 

Reduction of dienes incorporated into steroid structures may lead to different configurations in the products. For example, treatment of 8(9),14(15)-bisdehydroestrone 42 (R = H) for four hours at room temperature with twenty equivalents of trifluoroacetic acid and two equivalents of triethylsilane leads to an ionic hydrogenation product mixture containing the natural 8/1,9a,14a-estrone 43 as a minor component (11%) and the 8a,9/i, l 4/i-isomcr 44 as the major component (83%) (Eq. 92).241 The related methyl ether (42, R = Me) behaves in a similar fashion.241 The yield of natural isomer 46 formed from the methyl ether of A8(9),i4(i5)-bigdehydroestradiol analog 45 increases from 22 to 34%, and that of... 

Corbocyclic - The synthesis of 8a, 9p-estrone 3-methyl ether,87 the elusive boat C-ring Isomer, and 8a and 8a, 10a-19-nortestosterone88 have been reported. Recent approaches to the transformation of steroids to their A-homo derivatives include the... 

---