6a-Methylprednisolone

Methyl 3a,6a-dihydroxycholanate, 240 1-Methylestrone 3-methyl ether, 10, 27 4b/3-Methyl-7-ethylenedioxy-1,2,3,4, 4a ,4b/3,5,6,7,8,10,1 Oaa-dodecahydro-phenanthrene-1 /3,4/3-diol, 236 14C-Methyl iodide, 211 ds-Methyl iodide, 210, 214 Methyl lithocholate tosylate, 329 1-Methyl-19-nortestosterone, 27 6a-Methylprednisolone, 410 6a-Methylprednisolone BMD, 410 16/3-Methylprednisone, 87 18-Methylpregn-4-ene-3/3,17a,20f-triol, 243 20-Methylpregn-5-en-3/3-ol, 415 17a-Methylpregnenolone acetate, 48 17a-Methyltestosterone, 438 16/3-Methyl- 11a,17a,21 -trihydroxy- 5 /3-pregnane-3,20-dione 21-acetate, 299, 300 20-Methyl-3/3-trityloxypregn-5-ene, 415 3/3-Methoxycholestane, 136 1-Methoxycyclohexene, 18 3-Methoxyestra-3,5(10)-diene, 18, 27... 

Synonym. 6a-Methylprednisolone 21-Acetate Proprietary Names. Depo-Medrone Medrone (cream). 

Synonym. Sodium 6a-Methylprednisolone 21-Succinate Proprietary Name. Solu-Medrone C26H33NaOs = 496.5 CAS—2375-03-3... 

The same general scheme for introducing the 9a-fluoro substituent is applicable to corticoids that feature a 6a-methyl group. 6a-Methylprednisolone (9-4) provides the starting material for the synthesis of fluorometholone (23-5) (Scheme 7.23). The standard sequence is again used to introduce the 9a-fluoro function (9-4 23-1). The only readily accessible hydroxyl at C21 is next converted to the mesylate 23-3 by acylation with methanesulfonyl chloride. Treatment of that intermediate with sodium iodide replaces the mesylate to afford the more readily reducible 21-iodo... 

Simultaneous dexamethasone, hydrocortisone, 6a-methylprednisolone, prednisolone, prednisone... 

Sample preparation Condition a Sep-Pak C18 SPE cartridge with 10 mL MeOH and 10 mL water. 3 mL Perfusate + 500 ng 6a-methylprednisolone, add to the SPE cartridge, wash three times with 10 mL aliquots of water, elute with 5 mL MeOH. Evaporate the eluate to dryness under a stream of nitrogen at 35°, reconstitute the residue in 100 p,L mobile phase, inject a 50 xL aliquot. 

---