64Cu complex

An early account194 describes an attempt to use 64Cu complexes of haematoporphyrin, protoporphyrin, uroporphyrin, and coproporphyrin to detect tumors preferential localization in tumors was not observed. It needs to be recognized that metalation can change solution... 

Other advantages of PET imaging with metallic radionuclides are facile radiolabeling (i.e. certain 64Cu complexes radiolabel in less than lmin at room temperature (12)) and generator availability (for 68Ga). 

A number of novel dioxo variants of the tetraazamacrocycles have been synthesized and stability constants were measured with Cu2+.114 A few of these were further evaluated as chelating agents with 64Cu.115 Structural differences included ring size (from 12 to 14) and placement of the oxo groups. Of the six variations synthesized, only one, l,4,8,ll-tetraazacyclotetradecane-3-9-dione(14N402-3,9), readily formed a complex (Figure 9). 

Packard AB, Kronauge JF, Barbarics E, Kiani S, Treves ST. Synthesis and biodistribution of a lipophilic 64Cu-labeled monocationic copper(II) complex. Nucl Med Biol 2002 29 289-294. 

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