17P-estradiol

Another matrix diffusional implant consists of an outer layer of micronized, crystalline 17P-estradiol dispersed in siUcone mbber over a nonmedicated, cylindrical siUcone mbber core. The system, implanted subcutaneously in the ears of cattie, releases estradiol for up to 400 days with kinetics to improve growth rate and feed efficiency (83). 

ER B 14q22-q24 530 aa, 583 aa, further isoforms 17p-Estradiol (E2) AGGTCA Ovary, testis (Sertoli and Leydig cells, efferent ducts), prostate, bone, thymus, spleen, brain... 

Genistein Daidzen Glycitein IVP-Estradiol MCE-7 Custom Genistein 10 xM Daidzen 10 xM Glycitein 10 xM 17P-Estradiol 10 nM Gene name. Accession number, fold change in table 118... 

The estrogens are a family of hormones synthesized in a variety of tissues. 17P-Estradiol is the primary estrogen of ovarian origin. In some species, estrone, synthesized in numerous tissues, is more abundant. In pregnancy, relatively more estriol is produced, and this comes from the placenta. The general pathway and the subcellular localization of the enzymes involved in the early steps of estradiol synthesis are the same as those involved in androgen biosynthesis. Features unique to the ovary are illustrated in Figure 42-7. 

M. Adinolfi, A. Iadonisi, A. Pezzella, and A. Ravida, Regioselective phenol or carbinol glycosidation of 17p-estradiol and derivatives thereof, Synlett, 12 (2005) 1848-1852. 

The efficiency of type II organoclays in taking up organic pollutants from water is also apparent from the data in Figs. 7 and 8 showing the removal of naphthalene and 17P-estradiol (an endocrine-disrupting compound) by octadecyltrimethylammonium-montmorillonite (Yuan 2004). 

Fig. 8. Depletion of 17P-estradiol from aqueous solution after contact with octadecyltrimethylammonium (ODTMA)-montmorillonite. C denotes the concentration of the estrogen after a given contact time, while Co is the initial concentration. After Yuan (2004). 

Estrogen, xenoestrogens 17p-estradiol MCF7 Highly similar responses among [34]... 

Yoon Y, Westerhoff P, Snyder SA, Esparza M (2003) HPLC-fluorescence detection and adsorption of bisphenol A, 17P-estradiol, and 17a-ethynyl estradiol on powdered activated carbon. Water Res 37 3530-3537... 

Peterson E.W., R.K. Davis, and H.A. Omdroff (20(X)). 17p-estradiol as an indicator of animal waste contamination in mantled karst aquifers. Journal of Environmental Quality 29 826-834. 

FIGURE 7.1 The structural relationship between phytoestrogens and 17p-estradiol. 

Fig. (25). Molecular models of gancaonin R (75, ball and stick) and 17p-estradiol (92, stick) overlay of B ring of 75 and A ring of 92. These molecular models were minimized with MM2, and then calculated with...

Fig. (26). Structures of an imaginary compound (103) that built up with estrogenic steroids (104 - 100) having higher binding affinities than that of 17p-estradiol (92).

By our examination of the modeling as illustrated in Fig. (27), it was indicated that orientations of these estrogenic compounds in die binding site of the estrogen receptor relative to 17P-estradiol (92) depend on their... 

From the molecular modeling analyses of isoprenoid-substituted phenols that did not showed binding affinity for the estrogen receptor, it was indicated that the binding sites at C-3 and C-17 of 17P-estradiol are rigid, but the lipophilic pocket near C-4-C-7 is flexible. 

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