16a-Hydroxyprogesterone

Identification and Quantitation of 16a-Hydroxyprogesterone in Human Amniotic Fluid... 

Step 2. The procedure for preparing 12y9-bromoacetoxy-19-nor-4-androstene-3,17-dione from 12/3-hydroxy-19-nor-4-androstene-3,17-dione is similar to that employed for the synthesis of 16 -bromoacetoxypro-gesterone from 16a-hydroxyprogesterone. °... 

From perfusion data, it is known that the midterm fetus converts progesterone to 20a-dihydroprogcsterone, 16a-hydroxyprogesterone, cortisol, and corticosterone (Solomon et al., 1964 Bird et al., 1966) and to corticosterone sulfate and deoxycorticosterone sulfate (Bird et al., 1965). Most of these reactions take place principally in the adrenal tissue (see Section III, D, 2 b, 3 b, and E, 2 b). 

Pyridinol carbamate 16a,17a-Di hydroxyprogesterone Algestone acetophenide L-Diiodo thyronine Liothyronine p-Diisobutylphenol... 

Ap-63 Rahim, M. A., and Sih, C. J., J. Biol. Chem. 241. 3615 (1966). In vitro studies of oxygenase and esterase from Cylindrocarpon radicicola. Degradation of progesterone, 17a-hydroxyprogesterone, 16-dehydroprogesterone, deoxycorticosterone, and 16a, 17a-oxidoprogesterone to C-19 steroids. 

N-Bromosuccinimide and 70%-perchloric acid added to a soln. of 10 g. 16-methylene-17a-hydroxyprogesterone in dioxane-water, and allowed to stand 1 hr. at room temp. 10.8 g. 16j -bromomethyl-16a,17a-oxidoprogesterone refluxed 1 hr. with ca. 6 g. HBr in ether-dioxane 16-bromomethylene-17a-hydroxyprogesterone (Y 79%). F. e. with other halogens s. F. v. Werder et al., B. 95, 2110 (1962). 

Fig. 18. Schematic representation of the principal transformations of the Cu and Cl steroids and their conjugates in the fetal and placental compartments. Aj-P pregnenolone P progesterone ITd-IlO-Aj-P iTa-hydroxyprcgnenolone 17a-HO-P 17a-hydroxyprogesterone DTI A dehydroepiandrosterone AND androstenedione 17/J-.D1I-DHA androstenediol-lTp DIIA-S dehydroepiandrosterone sxilfate Ida-IIO-DHA 16a-hydroxydchydrocpiandrosterone 16 -1I0-D1IA-S 16a-hydroxydehydroepi-androstcrono sulfate androstenetriol-S androstenetriol sulfate E estriol Kj-S estriol sulfate T testosterone Ej estradiol Kj-S estradiol sulfate E[ estrone E -S estione sulfate.

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