Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

15A10

The safety of the cocaine vaccine TC-CD in former cocaine abusers has been evaluated in a Phase I clinical trial, and it was determined that the vaccine was well tolerated with dose-related increases in antibody levels.65 Two Phase II clinical trials have now been conducted.66,67 The vaccine was again well tolerated and subjects reported a reduction in cocaine s reinforcing effects. The antibody levels were detectable after the second dose, peaked at 8 to 12 weeks, and remained elevated for up to 6 months preliminary findings indicated a negative association between antibody level and cocaine use. Other anti-cocaine vaccines in development include a blocking antibody (ITAC-cocaine) and a monoclonal catalytic antibody (15A10). [Pg.87]

Figure 5.20 Hydrolysis of cocaine catalyzed by mAb 15A10. The abzyme was generated using a mimic of the tetrahedral activated complex, with a phosphate group replacing the carboxylic group (inset). Figure 5.20 Hydrolysis of cocaine catalyzed by mAb 15A10. The abzyme was generated using a mimic of the tetrahedral activated complex, with a phosphate group replacing the carboxylic group (inset).
Anthraquinones group Cochineal Colour Index 91 )15A10... [Pg.86]

See other pages where 15A10 is mentioned: [Pg.304]    [Pg.305]    [Pg.382]    [Pg.304]    [Pg.305]    [Pg.382]    [Pg.29]    [Pg.694]    [Pg.1456]    [Pg.319]    [Pg.204]    [Pg.286]    [Pg.304]    [Pg.305]    [Pg.382]    [Pg.304]    [Pg.305]    [Pg.382]    [Pg.29]    [Pg.694]    [Pg.1456]    [Pg.319]    [Pg.204]    [Pg.286]   
See also in sourсe #XX -- [ Pg.87 ]



SEARCH



© 2024 chempedia.info