SEARCH Articles Figures Tables A CRiE pattern obtained with two different concentrations of trypsin added to norma serum.The first dimension was carried out from left to right and the second dimension from bottom to top. Two separate gels are shown, with the highest trypsin concentration at the bottom. Antibody against tt -antitrypsin was present in the second dimension gel. The resulting pattern shows two distinct ai-antitrypsin species, the free protease inhibitor . This example illustrates the ability of CRIE to evaluate changes in specific protein structure. [Publishers Imprint]