Zoledronate adverse effects

Zoledronic acid 4 mg as a single intravenous infusion once yearly Effects on bone turnover and bone density were similar to those with daily oral bisphosphonates. Efficacy against fractures has not yet been established. Adverse effects include myalgia and pyrexia. 

Zoledronic acid has been used to counter the adverse effects of aromatase inhibitors on bone density [SEDA-32, 753]. It seems very likely that the risk of accelerated bone loss and consequent fractures during adjuvant aromatase inhibitor therapy would similarly be reduced by the use of denosu-mab, a fully human monoclonal antibody against receptor activator of NFk-B. A US group has reported on a group of 252 patients with breast cancer and low bone mass (but no osteoporosis) taking aromatase inhibitors for long periods [42 ]. All received supplementary calcium... 

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