Zoladex subcutaneous implant

Route of administration Zoladex is injected as a subcutaneous implant. The injection site of choice is the upper abdominal wall, but the midline of the lower abdomen has also been used. 

Goserelin (Zoladex), a hormonal antineoplastic drug used to treat breast cancer, is administered subcutaneously in an unusual way. The drag is contained in a dry pellet that is implanted in the soft tissue of the abdomen, where it is gradually absorbed during a period of 1 to 3 months. After a local anesthetic, such as lido-caine, is administered, a large needle (usually 16 gauge) is used to insert the pellet. 

Zoladex implants are indicated for use in the palliative treatment of advanced breast cancer in pre- and peri-menopausal women, in the palliative treatment of advanced carcinoma of the prostate and in the management of endometriosis, including pain relief and the reduction of endometriotic lesions. The implant is fabricated by dispersing goserelin in a PLGA matrix and molding it into a cylindrical shape, which can be injected subcutaneously. 

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